What's New in Malignant Mesothelioma Research and Treatment?

There is always research going on in the area of mesothelioma. Scientists are looking for causes and ways to prevent mesothelioma. Doctors are working to improve accuracy of diagnosis and effectiveness of treatment. Despite recent progress, much remains to be learned about the best way to treat these cancers.

Causes and Prevention

Much of the research on mesothelioma has focused on learning exactly how asbestos changes mesothelial cells and their DNA to cause these cancers. Understanding how these fibers produce cancer might help us develop ways to prevent those changes.

The risk of asbestos in developing mesothelioma is a definite public health concern. We are continuously learning more about which fibers can produce cancer, how they cause these cancers, and what levels of exposure can be considered safe. Now that we know about the dangers of asbestos, we can limit or stop exposure in homes, public buildings, and the workplace. Unfortunately, regulations protecting workers from asbestos exposure are much less stringent in some countries and nonexistent in others.

Multimodality Therapy

Doctors are always learning more about the best way to treat patients with mesotheliomas. The roles of surgery, radiation therapy, and chemotherapy in the treatment of mesothelioma are highly debated. Treatments that use some combinations of surgery, radiation therapy, and chemotherapy, called multimodality therapy, are now being studied and may provide the most promising option for some patients. New chemotherapy drugs are currently being tested in clinical trials, together with other types of treatment.

Gene Therapy

A new approach to cancer therapy being tested on mesothelioma is gene therapy. One of these approaches to treating mesothelioma, uses special viruses that have been modified in the laboratory. The modified virus is injected into the pleural space and infects the mesothelioma cells. When this infection occurs, the virus injects a gene into the mesothelioma that makes the cancer very sensitive to a drug that would otherwise not harm the cancer.

Immunotherapy

Treatments that boost the immune system's reaction to fight mesothelioma more effectively are being tested in clinical trials. Some of these treatments use interferons or interleukins, hormone-like substances that activate the immune system.